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1. (WO2018089378) METHODS FOR EXPRESSION PROFILE CLASSIFICATION

Pub. No.:    WO/2018/089378    International Application No.:    PCT/US2017/060451
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 08 00:59:59 CET 2017
IPC: G06F 19/10
G06F 19/20
G06F 19/24
Applicants: CELLULAR RESEARCH, INC.
Inventors: FAN, Jue
ZHANG, Jesse
HU, Jing
Title: METHODS FOR EXPRESSION PROFILE CLASSIFICATION
Abstract:
Disclosed herein are methods and systems for identifying targets for distinguishing cell types. In some embodiments, the method comprises: hierarchically clustering expression profiles of cells to generate a dendrogram with each leaf representing the expression profile of a different individual cell. The dendrogram can be pruned by eliminating invalid splits (and their children). The remaining leaves in the dendrogram can be merged, independent of their locations in the dendrogram, based on their distances to one another to generate clusters of expression profiles. The method can identify targets for distinguishing cell types based on targets that are expressed differentially in the clusters.