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Machine translation
1. (WO2018089360) PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/089360    International Application No.:    PCT/US2017/060392
Publication Date: 17.05.2018 International Filing Date: 07.11.2017
IPC:
C07D 471/04 (2006.01), A61K 31/4375 (2006.01), A61P 11/00 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543 (US)
Inventors: ZHAO, Guohua; (US).
MIGNONE, James; (US)
Agent: EPPERSON, James; (US).
BELLOMY, Gregory R.; (US).
CHAO, Yuan; (US).
CLAUSS, Isabelle M.; (US).
DELAUNEY, Ashton J.; (US).
FARQUHARSON-TORRES, Serena; (US).
GOLIAN, Paul D.; (US).
GREENBLATT, Gary D.; (US).
GUO, Z. Angela; (US).
HADAD, Henry; (US).
HAN, Bo; (US).
HAI, Bing; (US).
JACOBSEN, Barry H.; (US).
KORSEN, Elliott; (US).
LIU, Hong; (US).
LU, Yong; (US).
MINGO, Pamela A.; (US).
PARLET, Nickki L.; (US).
SUN, Jing G.; (US).
VANATTEN, Mary K.; (US).
VOM WEGE, Julia; (US).
WALSH, Brian J.; (US)
Priority Data:
62/418,833 08.11.2016 US
Title (EN) PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS
(FR) AMIDES DE PYRROLE EN TANT QU'INHIBITEURS D'INTÉGRINE ALPHA V
Abstract: front page image
(EN)The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
(FR)La présente invention concerne des composés de formule (I) ou des stéréoisomères, des tautomères ou des sels pharmaceutiquement acceptables ou des solvates de ceux-ci ; dans la formule, toutes les variables ayant la signification indiquée dans la description. Ces composés sont des inhibiteurs des intégrines contenant αv. La présente invention concerne également des compositions pharmaceutiques comprenant ces composés et des procédés de traitement d'une maladie, d'un trouble ou d'un état associé à un dérèglement d'intégrines contenant αv, tels que la fibrose pathologique, le rejet de greffe, le cancer, l'ostéoporose et les troubles inflammatoires, à l'aide des composés et des compositions pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)