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1. (WO2018089358) AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS

Pub. No.:    WO/2018/089358    International Application No.:    PCT/US2017/060390
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 08 00:59:59 CET 2017
IPC: C07D 471/04
A61K 31/4375
A61P 11/00
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: DEVASTHALE, Pratik
WANG, Wei
Title: AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS
Abstract:
The present invention provides compounds of Formula (I): (Formula (I)), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.