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1. (WO2018089328) TREATMENT OF CNS DISEASES WITH SGC STIMULATORS

Pub. No.:    WO/2018/089328    International Application No.:    PCT/US2017/060299
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 08 00:59:59 CET 2017
IPC: A61K 31/437
A61K 31/5025
A61K 31/506
A61K 31/519
A61P 25/00
Applicants: IRONWOOD PHARMACEUTICALS, INC.
Inventors: JUNG, Joon
LEE, Thomas, Wai-ho
IYENGAR, Rajesh, R.
PERL, Nicholas, Robert
GERMANO, Peter
RIBADENEIRA, Maria, D.
TANG, Kim
Title: TREATMENT OF CNS DISEASES WITH SGC STIMULATORS
Abstract:
The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3',5'-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.