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1. (WO2018089199) OXAZOLE DERIVATIVES FOR USE AS IRAK INHIBITORS AND METHOD FOR THEIR PREPARATION

Pub. No.:    WO/2018/089199    International Application No.:    PCT/US2017/058339
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Oct 26 01:59:59 CEST 2017
IPC: C07D 413/14
A61P 29/00
A61K 31/422
Applicants: RIGEL PHARMACEUTICALS, INC.
LI, Hui
HECKRODT, Thilo
CHEN, Yan
KELLEY, Ryan
MCMURTRIE, Darren
TSO, Kin
TAYLOR, Vanessa
SINGH, Rajinder
YEN, Rose
MAUNG, Jack
Inventors: LI, Hui
HECKRODT, Thilo
CHEN, Yan
KELLEY, Ryan
MCMURTRIE, Darren
TSO, Kin
TAYLOR, Vanessa
SINGH, Rajinder
YEN, Rose
MAUNG, Jack
Title: OXAZOLE DERIVATIVES FOR USE AS IRAK INHIBITORS AND METHOD FOR THEIR PREPARATION
Abstract:
Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, which are oxazole compounds of formula 1, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.