Search International and National Patent Collections

1. (WO2018088896) EARLY DNA ANALYSIS USING INCOMPLETE DNA DATASETS

Pub. No.:    WO/2018/088896    International Application No.:    PCT/NL2017/050721
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: G06F 19/22
Applicants: TECHNISCHE UNIVERSITEIT DELFT
Inventors: AL-ARS, Zaid
NAUMAN, Ahmed
BERTELS, Koenraad Laurent Maria
Title: EARLY DNA ANALYSIS USING INCOMPLETE DNA DATASETS
Abstract:
A method of analyzing sequencing data associated with a sample is disclosed. The method comprises receiving by a computer system a plurality of sequencing reads while a sequencing assay is in progress of sequencing the sequencing reads, wherein at least some of the sequencing reads are incomplete sequencing reads, wherein the incomplete sequencing reads are sequencing reads for which only a part of the base pairs of the sequencing read have been determined by the sequencing assay, and the missing base pairs are still in the process of being determined by the sequencing assay. Further, mapping by the computer system the plurality of sequencing reads to a reference sequence. Further, predicting at least some of the missing base pairs and quality values of an incomplete sequencing read based on available base pair information of the sequencing reads and applying the predicted base pairs and quality values to the sequencing read.