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1. (WO2018088732) OPTIMIZATION OF THE DESIGNING OF APPARATUS AND PROCESSES FOR MASS PRODUCTION OF MONODISPERSE BIODEGRADABLE POLYMER-BASED MICROSPHERES AND BIODEGRADABLE POLYMER-BASED DRUG DELIVERY SYSTEMS

Pub. No.:    WO/2018/088732    International Application No.:    PCT/KR2017/011915
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Fri Oct 27 01:59:59 CEST 2017
IPC: B01J 13/04
B01J 19/00
A61K 9/16
Applicants: INVENTAGE LAB. INC.
Inventors: KIM, Ju Hee
Title: OPTIMIZATION OF THE DESIGNING OF APPARATUS AND PROCESSES FOR MASS PRODUCTION OF MONODISPERSE BIODEGRADABLE POLYMER-BASED MICROSPHERES AND BIODEGRADABLE POLYMER-BASED DRUG DELIVERY SYSTEMS
Abstract:
a method and an apparatus for a large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems and design optimization method for the apparatus are provided. The method uses a plurality of microchips, each microchip having at least a first pathway, a second pathway and an outlet, wherein the first pathway and the second pathway merge at a cross point being one end of the outlet, and the method comprises preparing a polymer-phase solution including a degradable polymer and a water-phase solution including a surfactant, having the polymer-phase solution flow through the first pathway, having the water-phase solution flow through the second pathway, gathering a mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the water-phase solution.