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1. (WO2018088272) ENDOTHELIN-CONVERTING ENZYME INHIBITOR

Pub. No.:    WO/2018/088272    International Application No.:    PCT/JP2017/039319
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 01 00:59:59 CET 2017
IPC: A61K 36/81
A61K 36/90
A61K 36/185
A61K 36/48
A61K 36/67
A61P 9/12
A61P 17/18
A61Q 19/02
A61K 8/97
A61K 36/899
Applicants: KAO CORPORATION
CHULALONGKORN UNIVERSITY
Inventors: HASHIMOTO, Hiroshi
HOTTA, Mitsuyuki
BOONSRI, Ongpipattanakul
RUTT, Suttisri
CHUTIMA, Petchprayoon
WORATUCH, Thitikornpong
Title: ENDOTHELIN-CONVERTING ENZYME INHIBITOR
Abstract:
Provision of a material, which has activity of inhibiting endothelin-converting enzyme and is effective for skin whitening or antihypertension. An endothelin-converting enzyme inhibitor comprising, as an active ingredient, at least one selected from the group consisting of Hiptage candicans, Piper sarmentosum, Solanum stramonifolium, Anaxagorea luzonensis, Smilax corbularia, Ardisia elliptica, Erythrina suberosa, Dactyloctenium aegyptium, Hopea ferrea and extracts thereof.