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1. (WO2018087760) HIGHLY EFFICIENT AND TUNABLE SYSTEM FOR THE INCORPORATION OF UNNATURAL AMINO ACIDS INTO PROTEINS IN ESCHERICHIA COLI
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Pub. No.: WO/2018/087760 International Application No.: PCT/IL2017/051221
Publication Date: 17.05.2018 International Filing Date: 09.11.2017
IPC:
C12P 21/00 (2006.01) ,C12N 1/21 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
Applicants: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY[IL/IL]; P.O. Box 653 84105 Beer Sheva, IL
REGENTS OF THE UNIVERSITY OF MINNESOTA[US/US]; 600 McNamara Alumni Center 200 Oak Street SE Minneapolis, Minnesota 55455, US
Inventors: ALFONTA, Lital; IL
NOIREAUX, Vincent; US
SCHLESINGER, Orr; IL
CHEMLA, Yonatan; IL
OZER, Eden; IL
Agent: GEYRA, Assaf; IL
KESTEN, Dov; IL
GASSNER, Dvir; IL
Priority Data:
62/420,01010.11.2016US
Title (EN) HIGHLY EFFICIENT AND TUNABLE SYSTEM FOR THE INCORPORATION OF UNNATURAL AMINO ACIDS INTO PROTEINS IN ESCHERICHIA COLI
(FR) SYSTÈME HAUTEMENT EFFICACE ET RÉGLABLE POUR L'INCORPORATION D'ACIDES AMINÉS NON NATURELS DANS DES PROTÉINES DANS ESCHERICHIA COLI
Abstract:
(EN) The present invention provides a composition with a cell having an orthogonal translation system, and an expression vector. The invention also provides a method of producing a protein carrying an unnatural amino acid, and a kit for use in producing a protein carrying the unnatural amino acid.
(FR) La présente invention concerne une composition comprenant une cellule présentant un système de traduction orthogonale et un vecteur d'expression. L'invention concerne également un procédé de production d'une protéine portant un acide aminé non naturel et un kit destiné à être utilisé dans la production d'une protéine portant l'acide aminé non naturel.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)