Search International and National Patent Collections
|1. (WO2018087699) METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION|
|Applicants:||THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
THE TEXAS A&M UNIVERSITY SYSTEM
|Inventors:||DICKEY, Burton F.
TUVIM, Michael J.
EVANS, Scott E.
HUSTON, David P.
|Title:||METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION|
Embodiments are directed to methods and compositions for modulating an immune response. In certain aspects the immune response is a type I hypersensitivity response. In particular aspects the subject has allergic asthma or allergic rhinitis. Using a conventional experimental asthma mouse model (BALB/c), the inventors demonstrate that aerosol administration of TLR agonists, in particular a combination of TLR2/6 and TLR9 agonist (e.g., TLR9 oligonucleotide agonist / PAM2CSK4) along with an antigen (e.g., ovalbumin (OVA)) suppresses the immune response as exemplified by the production of antigen-specific IgE and decreases the number of airway eosinophils in bronchoalveolar lavage fluid (BAL) in response to intraperitoneal (IP) immunization with an antigen mixed with alum.