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1. (WO2018087699) METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION

Pub. No.:    WO/2018/087699    International Application No.:    PCT/IB2017/057025
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Fri Nov 10 00:59:59 CET 2017
IPC: A61P 11/00
A61P 37/02
A61P 37/08
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
PULMOTECT, INC.
THE TEXAS A&M UNIVERSITY SYSTEM
Inventors: DICKEY, Burton F.
TUVIM, Michael J.
EVANS, Scott E.
HOOK, Magnus
HUSTON, David P.
MARTINEZ-MOCZYGEMBA, Margarita
SCOTT, Brenton
Title: METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION
Abstract:
Embodiments are directed to methods and compositions for modulating an immune response. In certain aspects the immune response is a type I hypersensitivity response. In particular aspects the subject has allergic asthma or allergic rhinitis. Using a conventional experimental asthma mouse model (BALB/c), the inventors demonstrate that aerosol administration of TLR agonists, in particular a combination of TLR2/6 and TLR9 agonist (e.g., TLR9 oligonucleotide agonist / PAM2CSK4) along with an antigen (e.g., ovalbumin (OVA)) suppresses the immune response as exemplified by the production of antigen-specific IgE and decreases the number of airway eosinophils in bronchoalveolar lavage fluid (BAL) in response to intraperitoneal (IP) immunization with an antigen mixed with alum.