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1. (WO2018087641) COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF ACSL4-OVEREXPRESSING TUMORS
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Pub. No.: WO/2018/087641 International Application No.: PCT/IB2017/056879
Publication Date: 17.05.2018 International Filing Date: 03.11.2017
IPC:
A61K 31/15 (2006.01) ,A61K 31/337 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/704 (2006.01) ,A61K 45/06 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
15
Oximes (CN-O-); Hydrazines (N-N); Hydrazones (N-N)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
337
having four-membered rings, e.g. taxol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
704
attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
PODESTA, Ernesto J. [IT/AR]; AR
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) [AR/AR]; Godoy Cruz 2290 Ciudad Autónoma de Buenos Aires C1425FQB, AR
Inventors:
PODESTA, Ernesto J.; AR
CASTILLO, Ana F.; AR
ORLANDO, Ulises D.; AR
MALOBERTI, Paula M.; AR
SOLANO, Angela R.; AR
Priority Data:
62/419,01308.11.2016US
Title (EN) COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF ACSL4-OVEREXPRESSING TUMORS
(FR) COMPOSITIONS ET PROCÉDÉS POUR L'INHIBITION DE LA CROISSANCE DE TUMEURS SUREXPRIMANT L'ACSL4
Abstract:
(EN) Compositions and methods for inhibiting tumor growth, particularly breast cancer, in a combined pharmacological treatment. A pharmaceutical combination for inhibiting growth of a tumor overexpressing ACSL4, comprising a first and a second dosage forms, wherein: i) the first dosage form comprises an ACSL4 inhibitor; and ii) the second dosage form comprises a chemotherapeutic agent.
(FR) L'invention concerne des compositions et des procédés pour l'inhibition de la croissance de tumeurs, en particulier d'un cancer du sein, dans un traitement pharmacologique combiné. Plus précisément, l'invention concerne une association pharmaceutique pour l'inhibition de la croissance d'une tumeur surexprimant l'ACSL4, comprenant des première et seconde formes pharmaceutiques : i) la première forme pharmaceutique comprenant un inhibiteur de l'ACSL4 ; et ii) la seconde forme pharmaceutique comprenant un agent chimiothérapeutique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)