Search International and National Patent Collections

1. (WO2018087597) RECOMBINANT PMHC CLASS II MOLECULES

Pub. No.:    WO/2018/087597    International Application No.:    PCT/IB2017/001508
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: C07K 19/00
A61K 38/16
A61K 39/00
A61P 37/06
Applicants: UTI LIMITED PARTNERSHIP
Inventors: SANTAMARIA, Pedro
Title: RECOMBINANT PMHC CLASS II MOLECULES
Abstract:
Described herein are heterodimers containing at least one first polypeptide and at least one second polypeptide, wherein the first polypeptide and the second polypeptide meet at an interface, wherein the interface of the first polypeptide contains an engineered protuberance which is positionable in an engineered cavity in the interface of the second polypeptide; and (i) the first polypeptide contains an MHC class II α1 domain, an MHC class II α2 domain, or a combination thereof; and the second polypeptide comprises an MHC class II β1 domain, an MHC class II β2 domain, or a combination thereof; or (ii) the first polypeptide contains an MHC class II β1 domain, an MHC class II β2 domain, or a combination thereof; and the second polypeptide comprises an MHC class II α1 domain, an MHC class II α2 domain, or a combination thereof.