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1. (WO2018087547) METHOD FOR PREDICTING THE RESPONSE OF A SUBJECT WITH AN AUTOIMMUNE DISEASE TO A B CELL-TARGETING THERAPY

Pub. No.:    WO/2018/087547    International Application No.:    PCT/GB2017/053373
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Fri Nov 10 00:59:59 CET 2017
IPC: G01N 33/564
C12Q 1/68
C07K 16/28
Applicants: UCL BUSINESS PLC
Inventors: CAMBRIDGE, Geraldine
Title: METHOD FOR PREDICTING THE RESPONSE OF A SUBJECT WITH AN AUTOIMMUNE DISEASE TO A B CELL-TARGETING THERAPY
Abstract:
The present invention relates to a method for predicting the response of a subject with an autoimmune disease to a B cell-targeting therapy. In particular, the invention relates to predicting the response of a patient by analysing the level of soluble CD23 (sCD23) and B cell activation factor (BAFF) in a sample from said subject. The B cell-targeting therapy can be an anti-CD20 antibody. The autoimmune disease can be systemic lupus erythematosus (SLE). Methods of treatment, compositions and kits are disclosed.