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1. (WO2018087539) TAGLESS ENCODED CHEMICAL LIBRARY
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Pub. No.: WO/2018/087539 International Application No.: PCT/GB2017/053360
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
C12N 15/10 (2006.01) ,C12Q 1/6823 (2018.01) ,C40B 40/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
[IPC code unknown for C12Q 1/6823]
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
06
Libraries containing nucleotides or polynucleotides, or derivatives thereof
Applicants:
BACTEVO LTD [GB/GB]; Merrifield Centre Rosemary Lane Cambridge Cambridgeshire CB1 3LQ, GB
Inventors:
WILLIAMS, David Hugh; GB
MANDAL, Ipshita; GB
WOOD, Stuart Robert; GB
BRATTON, Daniel; GB
Agent:
SCHLICH LTD; HUTCHINS, Michael R. 9 St Catherine's Road Littlehampton West Sussex BN17 5HS, GB
Priority Data:
1618820.308.11.2016GB
1709718.919.06.2017GB
Title (EN) TAGLESS ENCODED CHEMICAL LIBRARY
(FR) BIBLIOTHÈQUE CHIMIQUE CODÉE SANS ÉTIQUETTE
Abstract:
(EN) Described is a method for screening an encoded chemical library, which library comprises a plurality of different chemical structures each releasably linked to an encoding tag, the method comprising the steps of: (a) providing said library of tagged chemical structures; (b) releasing each chemical structure from its tag to produce a plurality of free, tagless chemical structures (TCSs); (c) screening the TCSs by contacting them with a assay system under conditions whereby a spatial association between each TCS and its tag is maintained, to produce a plurality of different screened TCSs each spatially associated with its tag; and (d) identifying a screened TCS by decoding a tag that is spatially associated therewith.
(FR) L'invention concerne un procédé de criblage d'une bibliothèque chimique codée, ladite bibliothèque comprenant une pluralité de structures chimiques différentes, chacune étant liée de manière détachable à une étiquette de codage, le procédé comprenant les étapes consistant à : (a) utiliser ladite bibliothèque de structures chimiques étiquetées ; (b) détacher chaque structure chimique de son étiquette pour produire une pluralité de structures chimiques libres, sans étiquette (tagless chemical structures - TCS) ; (c) cribler les TCS par leur mise en contact avec un système de test dans des conditions permettant de maintenir une association spatiale entre chaque TCS et son étiquette, pour produire une pluralité de TCS criblées différentes, chacune étant spatialement associée à son étiquette ; et (d) identifier une TCS criblée par décodage d'une étiquette qui est spatialement associée à celle-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)