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1. (WO2018087527) PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS

Pub. No.:    WO/2018/087527    International Application No.:    PCT/GB2017/053336
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 08 00:59:59 CET 2017
IPC: C07D 417/14
C07D 405/14
C07D 413/14
C07D 403/14
C07D 471/04
A61P 35/00
A61K 31/506
A61K 31/5377
A61K 31/551
C07D 417/04
C07D 403/04
Applicants: CANCER RESEARCH TECHNOLOGY LIMITED
Inventors: CARSWELL, Emma L.
CHARLES, Mark David
EKWURU, Chukuemeka Tennyson
ELUSTONDO, Frédéric
FOWLER, Katherine M.
OTT, Gregory R.
ROFFEY, Jonathan R
BROOKFIELD, Joanna L.
FORD, Daniel James
CALDER, Mathew L.
Title: PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS
Abstract:
The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity Formula (I). The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.