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|1. (WO2018087527) PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS|
|Applicants:||CANCER RESEARCH TECHNOLOGY LIMITED
|Inventors:||CARSWELL, Emma L.
CHARLES, Mark David
EKWURU, Chukuemeka Tennyson
FOWLER, Katherine M.
OTT, Gregory R.
ROFFEY, Jonathan R
BROOKFIELD, Joanna L.
FORD, Daniel James
CALDER, Mathew L.
|Title:||PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS|
The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity Formula (I). The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.