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1. (WO2018087527) PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/087527 International Application No.: PCT/GB2017/053336
Publication Date: 17.05.2018 International Filing Date: 07.11.2017
IPC:
C07D 417/14 (2006.01) ,C07D 405/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 403/14 (2006.01) ,C07D 471/04 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/506 (2006.01) ,A61K 31/5377 (2006.01) ,A61K 31/551 (2006.01) ,C07D 417/04 (2006.01) ,C07D 403/04 (2006.01)
Applicants: CANCER RESEARCH TECHNOLOGY LIMITED[GB/GB]; Angel Building 407 St John Street London EC1V 4AD, GB
Inventors: CARSWELL, Emma L.; GB
CHARLES, Mark David; GB
EKWURU, Chukuemeka Tennyson; GB
ELUSTONDO, Frédéric; FR
FOWLER, Katherine M.; GB
OTT, Gregory R.; US
ROFFEY, Jonathan R; GB
BROOKFIELD, Joanna L.; GB
FORD, Daniel James; AU
CALDER, Mathew L.; GB
Agent: HGF LIMITED; 4th Floor, Merchant Exchange 17-19 Whitworth Street West Manchester M1 5WG, GB
Priority Data:
1618845.008.11.2016GB
Title (EN) PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS
(FR) DÉRIVÉS DE PYRIMIDINONE EN TANT QU'INHIBITEURS DE CDC7
Abstract: front page image
(EN) The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity Formula (I). The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
(FR) La présente invention concerne des composés de formule I tels que définis dans la description, et des sels et des solvates de ceux-ci, qui sont utiles en tant qu'inhibiteurs de formule d'activité enzymatique de kinase du cycle 7 (Cdc7) de division cellulaire. La présente invention concerne également des compositions pharmaceutiques comprenant ces composés, et leur utilisation dans le traitement de troubles prolifératifs, tel que le cancer, ainsi que d'autres maladies ou états dans lesquels l'activité de la kinase Cdc7 est impliquée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)