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1. (WO2018087413) RUTHENIUM COMPLEXES FOR TREATING CANCER WHICH COMPRISES CANCER STEM CELLS

Pub. No.:    WO/2018/087413    International Application No.:    PCT/ES2017/070745
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Sat Nov 11 00:59:59 CET 2017
IPC: C07F 15/00
A61K 31/555
Applicants: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
UNIVERSIDAD AUTÓNOMA DE MADRID
Inventors: RODRÍGUEZ VILLAR, Jessica
MASCAREÑAS CID, José Luis
RODRÍGUEZ COUCEIRO, José
MOSQUERA MOSQUERA, Jesús
VÁZQUEZ SENTÍS, Marcos Eugenio
SAINZ ANDING, Bruno
Title: RUTHENIUM COMPLEXES FOR TREATING CANCER WHICH COMPRISES CANCER STEM CELLS
Abstract:
The invention relates to ruthenium complexes for treating cancer which comprises cancer stem cells. The present invention relates to the use of ruthenium(II) complexes to prepare a medicinal product for treating cancer, especially cancer which comprises cancer stem cells. Said ruthenium complexes are able to selectively metallate the guanine quadruplexes, thus resulting in increased expression of the c-MYC oncogene. Said increase in the proportion of c-MYC may promote the differentiation of cancer stem cells.