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1. (WO2018087389) SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS

Pub. No.:    WO/2018/087389    International Application No.:    PCT/EP2017/079181
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 15 00:59:59 CET 2017
IPC: C07D 471/04
C07D 471/16
C07D 487/04
A61K 31/407
A61P 35/00
Applicants: MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT
FORSCHUNGSVERBUND BERLIN E.V.
Inventors: SCHEIDEREIT, Claus
WILLENBROCK, Michael
LINDEMANN, Peter
RADETZKI, Silke
VON KRIES, Jens Peter
NAZARE, Marc
Title: SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS
Abstract:
The invention relates to chemical compounds and their use as a medicament in the treatment of a disease associated with genotoxic stress-induced I KK/NF-κΒ (NF-kappaB) activation, preferably in the treatment of a subject suffering from cancer exhibiting genotoxic stress-induced I KK/NF-κΒ activation. The invention further relates to a pharmaceutical composition comprising a compound of the invention for the treatment of a subject afflicted by a disease associated with genotoxic stress-induced I KK/NF-κΒ activation.