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1. (WO2018087359) TGF-BETA OLIGONUCLEOTIDE FOR USE IN TREATMENT OF OPHTHALMIC DISEASES

Pub. No.:    WO/2018/087359    International Application No.:    PCT/EP2017/079032
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Tue Nov 14 00:59:59 CET 2017
IPC: C12N 15/113
A61K 31/712
A61K 31/7125
Applicants: ISARNA THERAPEUTICS GMBH
Inventors: LEO, Eugen
JANICOT, Michel
WOSIKOWSKI-BUTERS, Katja
FETTES, Petra
Title: TGF-BETA OLIGONUCLEOTIDE FOR USE IN TREATMENT OF OPHTHALMIC DISEASES
Abstract:
The present invention is directed to an oligonucleotide comprising a nucleic acid sequence of SEQ ID No. 1 or parts thereof, wherein 1 to 4 nucleotides at the 3´-end and/or at the 5´-end of the oligonucleotide are modified at a base, a sugar and/or a phosphate for use in a method of reducing or inhibiting of scarring, of fibrotic closure of the trabeculectomy canal, of epithelial-to-mesenchymal transition of the trabecular meshwork and/or providing of protecting activity of the optic nerve optionally the optic nerve head. Further, the present invention refers to a pharmaceutical composition comprising such oligonucleotide and a pharmaceutically acceptable carrier.