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1. (WO2018087347) USE OF NON-TRANSITION METAL COORDINATED DIPYRIDOXYL COMPOUNDS TO PREVENT AND TREAT CHEMOTHERAPY-INDUCED PSN
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Pub. No.: WO/2018/087347 International Application No.: PCT/EP2017/078982
Publication Date: 17.05.2018 International Filing Date: 13.11.2017
Chapter 2 Demand Filed: 13.09.2018
IPC:
A61K 45/06 (2006.01) ,A61K 31/444 (2006.01) ,A61K 31/555 (2006.01) ,A61K 31/675 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
555
containing heavy metals, e.g. hemin, hematin, melarsoprol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
Applicants: KARLSSON-TUNER INVEST AS[NO/NO]; Mellomila 91B 7018 Trondheim, NO
Inventors: KARLSSON, Jan-Olof G; NO
JYNGE, Per; NO
ANDERSSON, Rolf GG; SE
Agent: CARLSSON, Fredrik; Ström & Gulliksson Box 5275 102 46 Stockholm, SE
Priority Data:
62/497,21414.11.2016US
Title (EN) USE OF NON-TRANSITION METAL COORDINATED DIPYRIDOXYL COMPOUNDS TO PREVENT AND TREAT CHEMOTHERAPY-INDUCED PSN
(FR) UTILISATION DE COMPOSÉS DE DIPYRIDOXYLE À COORDINATION MÉTALLIQUE NON-TRANSITION POUR PRÉVENIR ET TRAITER UNE NSP INDUITE PAR UNE CHIMIOTHÉRAPIE
Abstract:
(EN) There is disclosed a platinum ion chelating dipyridoxyl compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein the dipyridoxyl compound is uncoordinated or coordinated with a metal ion which is not a transition metal, for prevention or treatment of chemotherapy drug induced peripheral sensory neuropathy in a patient, wherein the chemotherapy drug comprises platinum ions. An example of such a chemotherapy drug is oxaliplatin. The drawbacks of previous metal complexed compounds containing manganese ions are eliminated. A more frequent use of the drug is possible since the problem in the prior art with accumulated manganese neurotoxicity is eliminated. The compounds can be administered both temporally and spatially separately from chemotherapy.
(FR) La présente invention concerne un composé de dipyridoxyle chélatant les ions de platine selon la formule I, ou un sel pharmaceutiquement acceptable de celui-ci, le composé de dipyridoxyle étant non coordonné ou coordonné avec un ion métallique qui n'est pas un métal de transition, pour la prévention ou le traitement d'une neuropathie sensitive périphérique induite par un médicament de chimiothérapie chez un patient, le médicament de chimiothérapie comprenant des ions de platine. Un exemple d'un tel médicament de chimiothérapie est l'oxaliplatine. Les inconvénients des composés complexes métalliques précédents contenant des ions manganèse sont éliminés. Une utilisation plus fréquente du médicament est possible étant donné que le problème de l'art antérieur dû à la neurotoxicité du manganèse accumulé est éliminé. Les composés peuvent être administrés séparément à la fois temporellement et spatialement de la chimiothérapie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)