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1. (WO2018087285) OR10H1 ANTIGEN BINDING PROTEINS AND USES THEREOF
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Pub. No.: WO/2018/087285 International Application No.: PCT/EP2017/078883
Publication Date: 17.05.2018 International Filing Date: 10.11.2017
IPC:
C07K 14/705 (2006.01) ,C07K 16/28 (2006.01) ,C12N 15/113 (2010.01) ,G01N 33/574 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS [DE/DE]; Im Neuenheimer Feld 280 69120 Heidelberg, DE
Inventors:
MEIER-EWERT, Sebastian; DE
KHANDELWAL, Nisit; DE
BECKHOVE, Philipp; DE
MICHELS, Tillmann; DE
BOUTROS, Michael; DE
BREINIG, Marco; DE
SORRENTINO, Antonio; DE
VOLPIN, Valentina; DE
Agent:
DÖRRIES, Hans Ulrich; DE
Priority Data:
16198189.910.11.2016EP
62/420,01510.11.2016US
PCT/EP2016/07728810.11.2016EP
Title (EN) OR10H1 ANTIGEN BINDING PROTEINS AND USES THEREOF
(FR) PROTÉINES DE LIAISON À L'ANTIGÈNE OR10H1 ET LEURS UTILISATIONS
Abstract:
(EN) The invention provides antigen binding proteins that bind to one or more extracellular domains of the human olfactory receptor 10H1 (OR10H1 ) or variants thereof, including antigen binding proteins which can modulate the expression, function, activity and/or stability of such receptor, as well as providing nucleic acids encoding such antigen binding proteins or components thereof. Methods for detecting OR10H1 or variants thereof in a sample, including diagnostic methods, using such antigen binding proteins are also provided. Uses of such antigen binding proteins, and nucleic acids encoding the same, in medicine are further provided.
(FR) L'invention concerne des protéines de liaison à l'antigène qui se lient à un ou plusieurs domaines extracellulaires du récepteur olfactif humain 10H1 (OR10H1) ou des variants de celui-ci, comprenant des protéines de liaison à l'antigène qui peuvent moduler l'expression, la fonction, l'activité et/ou la stabilité dudit récepteur, ainsi que des acides nucléiques codant pour de telles protéines de liaison à l'antigène ou des composants de celles-ci. L'invention concerne également des procédés de détection d'OR10H1 ou des variants de celui-ci dans un échantillon, y compris des procédés de diagnostic, utilisant de telles protéines de liaison à l'antigène. L'invention concerne en outre des utilisations de ces protéines de liaison à l'antigène, et des acides nucléiques codant pour celles-ci, en médecine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)