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1. (WO2018087155) AUTOMATED TISSUE DISSECTION INSTRUMENT AND METHODS OF USING THE SAME

Pub. No.:    WO/2018/087155    International Application No.:    PCT/EP2017/078623
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: G01N 1/04
G01N 1/28
G01N 1/38
Applicants: F. HOFFMANN-LA ROCHE AG
ROCHE DIAGNOSTICS GMBH
ROCHE SEQUENCING SOLUTIONS, INC.
VENTANA MEDICAL SYSTEMS, INC
Inventors: ADEY, Nils
AMERY, Dale
GUERRERO, Rene
NAOURI, Emmanuel
PARRY, Robert
ROMANOWICH, Peter
FOMIN, Leonid
Title: AUTOMATED TISSUE DISSECTION INSTRUMENT AND METHODS OF USING THE SAME
Abstract:
A system, an instrument, a computer-implemented method, and a clinical workflow for mesodissection of biological specimens on tissue slides by incorporating annotations. An image of an annotated reference slide is acquired and transposed onto a plurality of serial samples on the tissue slides along with the corresponding annotations and metadata. The serial samples are milled based on the annotations, and the milled tissue is automatically collected along with a milling buffer solution inside milling tips, and then dispensed in designated collection vials. The instrument automates the filling of aqueous buffer inside the milling tips and the monitoring of the buffer solution and the sequential filling of the milling tips. The workflow provides an integrated interface that performs tissue annotation, alignment, dissection, tracking, and reporting on a single screen. The degree of precision, ease of use and repeatability will improve PCR and NGS test results, ultimately providing timely patient results.