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1. (WO2018087126) AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/087126    International Application No.:    PCT/EP2017/078567
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
C07D 401/14 (2006.01), A61K 31/352 (2006.01), A61K 31/357 (2006.01), A61K 31/416 (2006.01), A61K 31/4188 (2006.01), A61K 31/426 (2006.01), A61K 31/4375 (2006.01), A61K 31/44 (2006.01), A61K 31/4439 (2006.01), A61K 31/47 (2006.01), A61K 31/498 (2006.01), A61K 31/519 (2006.01), C07D 213/72 (2006.01), C07D 213/81 (2006.01), C07D 311/18 (2006.01), C07D 215/48 (2006.01), C07D 215/54 (2006.01), C07D 319/18 (2006.01), C07D 231/54 (2006.01), C07D 401/12 (2006.01), C07D 241/44 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 277/56 (2006.01), C07D 513/04 (2006.01)
Applicants: BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 178 13353 Berlin (DE)
Inventors: BUCHGRABER, Philipp; (DE).
EIS, Knut; (DE).
WAGNER, Sarah; (DE).
SÜLZLE, Detlev; (DE).
BENDER, Eckhard; (DE).
LI, Volkhart, Min-Jian; (DE).
LIU, Ningshu; (DE).
SIEGEL, Franziska; (DE).
LIENAU, Philip; (DE)
Agent: BIP PATENTS; Alfred-Nobel-Str. 10 40789 Monheim am Rhein NRW (DE)
Priority Data:
16197975.2 09.11.2016 EP
Title (EN) AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE
(FR) DÉRIVÉS DE CYCLOHEXANE À SUBSTITUTION AMIDO EN TANT QU'INHIBITEURS DE TANKYRASE
Abstract: front page image
(EN)The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
(FR)La présente invention concerne des composés de cyclohexane à substitution amido de formule générale (I), dans laquelle A, R4, R6, R7, R8, R9, R10 et R11 sont tels que définis dans la description, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions et des combinaisons pharmaceutiques comprenant lesdits composés et l'utilisation desdits composés pour fabriquer une composition pharmaceutique pour le traitement ou la prophylaxie d'une maladie, en particulier les néoplasmes, en monothérapie ou en association avec d'autres principes actifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)