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1. (WO2018087108) PROTEINS SPECIFIC FOR CD137

Pub. No.:    WO/2018/087108    International Application No.:    PCT/EP2017/078522
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: C07K 14/47
A61K 38/17
C12N 5/10
C12N 15/00
Applicants: PIERIS PHARMACEUTICALS GMBH
Inventors: HINNER, Marlon
OLWILL, Shane
EICHNER, Timo
Title: PROTEINS SPECIFIC FOR CD137
Abstract:
The present disclosure provides human lipocalin muteins that bind CD137 and can be used in pharmaceutical applications, for example, as anti-cancer agents and/or immune modulators for the treatment or prevention of human diseases such as cancer, infectiousdiseases, and autoimmune diseases. The present discloser further shows the human lipocalin muteins can compete with CD137L for CD137 binding. The present disclosure also concerns methods of making CD137 binding lipocalin muteins described herein as well as compositions comprising such lipocalin muteins. The present disclosure further relates to nucleic acid molecules encoding such lipocalin muteins and to methods for generation of such lipocalin muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these lipocalin muteins as well as compositions comprising one or more of such lipocalin muteins.