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1. (WO2018086626) COMPOUND HAVING ANTI-TUMOUR EFFECT

Pub. No.:    WO/2018/086626    International Application No.:    PCT/CN2017/110889
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 15 00:59:59 CET 2017
IPC: A61K 31/546
A61P 35/00
Applicants: HJ CENTURY BIOPHARMACEUTICAL INC.
武汉华杰世纪生物医药有限公司
LI, Hua
李华
Inventors: LI, Hua
李华
CHEN, Jie
陈捷
ZHENG, Mengzhu
郑梦竹
LUAN, Shanshan
栾珊珊
Title: COMPOUND HAVING ANTI-TUMOUR EFFECT
Abstract:
The present invention relates to the field of medical technology, and in particular relates to the use of (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[1-(carboxymethyl)tetrazol-5-yl]thiomethyl]-8-oxo-5-thio-1-azabicyclo[4.2.0]octyl-2-ene-2-carboxylic acid (compound I) or a pharmaceutically acceptable salt thereof in the preparation of a drug, wherein the drug is used to prevent and/or treat neoplastic diseases in a subject. The present invention also relates to the use of compound I in the preparation of a kit, wherein the kit is used to reduce or inhibit the activity of TOPK in a cell.