WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018086626) COMPOUND HAVING ANTI-TUMOUR EFFECT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/086626 International Application No.: PCT/CN2017/110889
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
A61K 31/546 (2006.01) ,A61P 35/00 (2006.01)
Applicants: LI, Hua[CN/CN]; CN
HJ CENTURY BIOPHARMACEUTICAL INC.[CN/CN]; Biolake B1, No. 666, Gaoxin Road Wuhan East Lake High-Tech Development Zone Wuhan, Hubei 430075, CN
Inventors: LI, Hua; CN
CHEN, Jie; CN
ZHENG, Mengzhu; CN
LUAN, Shanshan; CN
Agent: CCPIT PATENT AND TRADEMARK LAW OFFICE; 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street, Xicheng District Beijing 100037, CN
Priority Data:
201611002636.514.11.2016CN
Title (EN) COMPOUND HAVING ANTI-TUMOUR EFFECT
(FR) COMPOSÉ ANTICANCÉREUX
(ZH) 具有抗肿瘤作用的化合物
Abstract:
(EN) The present invention relates to the field of medical technology, and in particular relates to the use of (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[1-(carboxymethyl)tetrazol-5-yl]thiomethyl]-8-oxo-5-thio-1-azabicyclo[4.2.0]octyl-2-ene-2-carboxylic acid (compound I) or a pharmaceutically acceptable salt thereof in the preparation of a drug, wherein the drug is used to prevent and/or treat neoplastic diseases in a subject. The present invention also relates to the use of compound I in the preparation of a kit, wherein the kit is used to reduce or inhibit the activity of TOPK in a cell.
(FR) L’invention se rapporte au domaine technique de la médecine, plus particulièrement à l’utilisation d’un composé (I) (6R,7R)-7-[[2-[2-(aminométhyl)phényl]acétyl]amino]-3-[[1-(carboxyméthyl)tétrazole-5-yl]métyhl sulfure]-8-oxo-5-thio-1-di-aza[4.2.0]octo-2-alcène-2-acide carboxylique ou son sel pharmaceutiquement acceptable pour la préparation d’un médicament remarquable en ce qu’il est indiqué pour la prévention et/ou le traitement de tumeurs. L’invention concerne l’utilisation d’un composé I dans la préparation d’une trousse d'analyse, laquelle est destinée à réduire ou inhiber l'activité TOPK dans les cellules affectées.
(ZH) 本发明涉及医药技术领域,特别涉及(6R,7R)-7-[[2-[2-(氨基甲基)苯基]乙酰]氨基]-3-[[1-(羧甲基)四唑-5-基]硫甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸(化合物I)或其可药用盐在制备药物中的用途,其中,所述药物用于预防和/或治疗受试者的肿瘤疾病。本发明还涉及化合物I在制备试剂盒中的用途,其中,所述试剂盒用于降低或抑制细胞中TOPK的活性。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)