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1. (WO2018086594) GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC TIM-3

Pub. No.:    WO/2018/086594    International Application No.:    PCT/CN2017/110494
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Sat Nov 11 00:59:59 CET 2017
IPC: A01K 67/00
C12N 15/63
C12N 15/00
C12N 15/09
Applicants: BEIJING BIOCYTOGEN CO., LTD
Inventors: SHEN, Yuelei
NI, Jian
GUO, Yanan
HUANG, Rui
ZHANG, Meiling
ZHAO, Lei
BAI, Yang
Title: GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC TIM-3
Abstract:
Disclosed herein are genetically modified non-human animals that express a human or chimeric (e.g., humanized) T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), and methods of use thereof.