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1. (WO2018086585) NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/086585    International Application No.:    PCT/CN2017/110438
Publication Date: 17.05.2018 International Filing Date: 10.11.2017
IPC:
C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 209/48 (2006.01), C07D 239/80 (2006.01), C07D 209/46 (2006.01), A61K 31/517 (2006.01), A61K 31/437 (2006.01), A61K 31/5025 (2006.01), A61K 31/404 (2006.01), A61P 11/00 (2006.01), A61P 29/00 (2006.01)
Applicants: SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD. [CN/CN]; Road Luo 7, National High & New Technology Industries Development Zone Linyi, Shandong 276017 (CN).
LUOXIN BIOTECHNOLOGY (SHANGHAI) CO., LTD. [CN/CN]; No.11, Lane 67, Libing Road Pilot Free Trade Zone Shanghai 201203 (CN)
Inventors: HU, Yonghan; (CN).
CAI, Dongmei; (CN).
DONG, Ping; (CN).
ZHU, Jiuxiang; (CN).
LI, Manhua; (CN).
DONG, Jiaqiang; (CN).
WANG, Tielin; (CN)
Agent: SHANGHAI BESHINING LAW OFFICE; 21st Floor, SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032 (CN)
Priority Data:
201610989839.1 10.11.2016 CN
Title (EN) NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF
(FR) COMPOSÉS HÉTÉROCYCLIQUES CONTENANT DE L'AZOTE, LEUR PROCÉDÉ DE PRÉPARATION, COMPOSITION PHARMACEUTIQUE ET UTILISATIONS ASSOCIÉES
(ZH) 一种含氮杂环类化合物、其制备方法、药物组合物及应用
Abstract: front page image
(EN)Disclosed in the present invention are nitrogen-containing heterocyclic compounds, a preparation method therefor, a pharmaceutical composition thereof, and applications thereof. The nitrogen-containing heterocyclic compounds represented by formula II can be effectively combined with bromodomains of BRD4, BRD3, BRD2 and BRDT of a BET family, and play a specific role.
(FR)La présente invention concerne des composés hétérocycliques contenant de l'azote, leur procédé de préparation, une composition pharmaceutique de ceux-ci, et leurs applications. Les composés hétérocycliques contenant de l'azote représentés par la formule II peuvent être efficacement combinés avec des bromodomaines de BRD4, BRD3, BRD2 et BRDT d'une famille BET, et jouent un rôle spécifique.
(ZH)本发明公开了一种含氮杂环类化合物、其制备方法、药物组合物及应用。本发明的如式II所示的含氮杂环类化合物可有效地结合BET家族BRD4、BRD3、BRD2和BRDT的溴结构域,发挥特定作用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)