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1. (WO2018086118) FORMATE DEHYDROGENASE MUTANT HAVING IMPROVED ENZYME ACTIVITY AND STABILITY, AND CONSTRUCTION METHOD THEREFOR
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Pub. No.: WO/2018/086118 International Application No.: PCT/CN2016/105699
Publication Date: 17.05.2018 International Filing Date: 14.11.2016
IPC:
C12N 9/02 (2006.01) ,C12N 15/53 (2006.01) ,C12N 15/70 (2006.01) ,C12N 1/21 (2006.01) ,C12R 1/19 (2006.01)
Applicants: JIANGNAN UNIVERSITY[CN/CN]; Xiaoyue Geng No. 1800 Lake Avenue Wuxi, Jiangsu 214122, CN
Inventors: RAO, Zhiming; CN
ZHENG, Junxian; CN
YANG, Taowei; CN
ZHOU, Junping; CN
ZHANG, Xian; CN
XU, Meijuan; CN
Agent: HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD.; Xiaoyue Geng Room E501, Building 18 Science and Technology 1St Street No.99 District Songbei, Harbin, Heilongjiang 150028, CN
Priority Data:
201610978442.208.11.2016CN
Title (EN) FORMATE DEHYDROGENASE MUTANT HAVING IMPROVED ENZYME ACTIVITY AND STABILITY, AND CONSTRUCTION METHOD THEREFOR
(FR) MUTANT DE FORMIATE DÉSHYDROGÉNASE PRÉSENTANT UNE ACTIVITÉ ENZYMATIQUE ET UNE STABILITÉ AMÉLIORÉES, ET SON PROCÉDÉ DE CONSTRUCTION
(ZH) 一种酶活和稳定性提高的甲酸脱氢酶突变体及其构建方法
Abstract:
(EN) A formate dehydrogenase mutant having improved enzyme activity and stability, and a construction method therefor. According to the mutant, on the basis of amino acid shown in SEQ ID No.2, alanine in the tenth site is mutated into cysteine.
(FR) L'invention concerne un mutant de formiate déshydrogénase présentant une activité enzymatique et une stabilité améliorées, et son procédé de construction. D'après le mutant, sur la base d'un acide aminé représenté dans SEQ ID No. 2, l'alanine présente dans le dixième site est mutée en cystéine.
(ZH) 提供了一种酶活和稳定性提高的甲酸脱氢酶突变体及其构建方法,所述突变体是在SEQ ID NO.2所示的氨基酸的基础上,将第10位丙氨酸突变成半胱氨酸。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)