Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018085955) METHOD FOR PRODUCING A SEA URCHIN EXTRACT ENRICHED WITH 1,4-POLYHYDROXYLATED NAPHTHOQUINONES WITH ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/085955 International Application No.: PCT/CL2017/050064
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
A61K 35/616 (2015.01)
[IPC code unknown for A61K 35/616]
Applicants:
UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA [CL/CL]; Av. España 1680 Valparaíso, 2390123, CL
KNOP LABORATORIOS S.A. [CL/CL]; Av. Industrial 1198 Quilpué, 2420598, CL
Inventors:
SEEGER, Michael; CL
STRAHSBURGER, Erwin; CL
GONZÁLEZ, Myriam; CL
CÁRDENAS, Franco; CL
Agent:
ALBA PROFESIONALES; Lota 2267 oficina 211 Providencia Santiago, 8340386, CL
BARRAZA, Carola; CL
Priority Data:
2895-201614.11.2016CL
Title (EN) METHOD FOR PRODUCING A SEA URCHIN EXTRACT ENRICHED WITH 1,4-POLYHYDROXYLATED NAPHTHOQUINONES WITH ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
(FR) MÉTHODE DE PRODUCTION D’UN EXTRAIT D’OURSINS DE MER ENRICHIS EN 1,4-NAPHTHOQUINONES POLYHYDROXYLÉES AYANT DES ACTIVITÉS ANTIMICROBIENNES ET ANTIOXYDANTES
(ES) UN MÉTODO PARA PRODUCIR UN EXTRACTO DE ERIZOS MARINOS ENRIQUECIDO EN 1,4-NAFTOQUINONAS POLIHIDROXILADAS CON ACTIVIDADES ANTIMICROBIANAS Y ANTIOXIDANTES
Abstract:
(EN) The invention relates to a method for obtaining 1,4-polyhydroxylated naphthoquinones from live sea urchins, which comprises the following steps: (a) injecting a saline solution of KCl into the perivisceral coelom of female sea urchins to induce spawning; (b) collecting and grinding the roe to obtain a fine powder; (c) mixing said fine powder with an alcoholic solvent; and (d) separating the alcoholic supernatant comprising the 1,4-polyhydroxylated naphthoquinones in solution. According to the invention, the 1,4-polyhydroxylated naphthoquinones are chosen from: equinochrome A (6-ethyl-2,3,5,7,8-pentahydroxy-1,4-naphthoquinone), spinochrome A (2-acetyl-3,5,6,8-tetrahydroxy-1,4-naphthoquinone), spinochrome B (2,3,5,7-tetrahydroxy-1,4-naphthoquinone), spinochrome C (2-acetyl-3,5,6,7,8-pentahydroxy-1,4-naphthoquinone), spinochrome D (2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), spinochrome E (hexahydroxy-1,4-naphthoquinone) or mixtures thereof.
(FR) La présente invention concerne une méthode pour obtenir des 1,4-naphthoquinones polyhydroxylées à partir d’oursins de mer vivants, laquelle méthode comprend les étapes suivantes: a) l’injection d’une solution saline de KCl dans le coelome périviscéral d’oursins de mer femelles pour induire le frai; b) la collecte des oeufs et le broyage des oeufs en une poudre fine; c) le mélange de ladite poudre fine avec un solvant alcoolique; d) la séparation du surnageant alcoolique qui comprend les 1,4-naphthoquinones polyhydroxylées en solution. Parmi les 1,4-naphthoquinones polyhydroxylées on trouve: l’échinochrome A (6-éthyl-2,3,5,7,8-pentahydroxy1,4-naphthoquinone), le spinochrome A (2-acétyl-3,5,6,8-tétrahydroxy-1,4-naphthoquinone), le spinochrome B (2,3,5,7-tétrahydroxy-1,4-naphthoquinone), le spinochrome C (2- acétyl-3,5,6,7,8- pentahydroxy-1,4-naphthoquinone), le spinochrome D (2,3,5,6,8-pentahydroxy- 1,4-naphthoquinone), le spinochrome E (hexahydroxy-1,4-naphthoquinone) ou leurs mélanges.
(ES) La invención se refiere a un método para obtener 1,4-naftoquinonas polihidroxiladas desde erizos de mar vivos, que comprende las siguientes etapas: a) inyectar una solución salina de KCl en el celoma perivisceral de erizos de mar hembra para inducir el desove; b) recolectar las ovas, y molerlas hasta obtener un polvo fino; c) mezclar dicho polvo fino con un solvente alcohólico; d) separar el sobrenadante alcohólico que comprende las 1,4-naftoquinonas polihidroxiladas en solución. Donde las 1,4-naftoquinonas polihidroxiladas se escogen entre: equinocromo A (6-etil- 2,3,5,7,8-pentahidroxi-1,4-naftoquinona), espinocromo A (2-acetil-3,5,6,8-tetrahidroxi-1,4- naftoquinona), espinocromo B (2,3,5,7-tetrahidroxi-1,4-naftoquinona), espinocromo C (2- acetil-3,5,6,7,8- pentahidroxi-1,4-naftoquinona), espinocromo D (2,3,5,6,8-pentahidroxi- 1,4-naftoquinona), espinocromo E (hexahidroxi-1,4-naftoquinona) o sus mezclas.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)