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1. (WO2018085775) METHODS AND COMPOSITIONS FOR TREATING MULTIPLE MYELOMA AND INCREASING ANTIBODY DEPENDENT CELL CYTOTOXICITY BY TARGETING THE ARYL HYDROCARBON RECEPTOR
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Pub. No.: WO/2018/085775 International Application No.: PCT/US2017/060201
Publication Date: 11.05.2018 International Filing Date: 06.11.2017
IPC:
A61K 39/00 (2006.01) ,C12N 5/02 (2006.01) ,A61K 9/127 (2006.01) ,A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
02
Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants: OHIO STATE INNOVATION FOUNDATION[US/US]; 1524 North High Street Columbus, Ohio 43201, US
Inventors: BENSON, Don; US
HUGHES, Tiffany; US
LEE, Robert J.; US
Agent: CLEVELAND, Janell T.; US
HALL, Miles E.; US
MEUNIER, Andrew T.; US
CARLIN, Gregory J.; US
CURFMAN, Christopher L.; US
Priority Data:
62/417,51004.11.2016US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING MULTIPLE MYELOMA AND INCREASING ANTIBODY DEPENDENT CELL CYTOTOXICITY BY TARGETING THE ARYL HYDROCARBON RECEPTOR
(FR) MÉTHODES ET COMPOSITIONS POUR TRAITER LE MYÉLOME MULTIPLE ET ACCROITRE LA CYTOTOXICITÉ CELLULAIRE ANTICORPS-DÉPENDANTE PAR CIBLAGE DU RÉCEPTEUR D'HYDROCARBURE ARYLE
Abstract:
(EN) Disclosed herein are methods and compositions for treating multiple myeloma, and for enhancing antibody-dependent cellular toxicity (ADCC). Specifically, disclosed herein are methods of using antagonists of the aryl hydrocarbon receptor (AHR) to treat multiple myeloma and enhance ADCC. Also specifically disclosed is liposomal CH233191.
(FR) L'invention concerne des méthodes et des compositions pour traiter le myélome multiple, et pour améliorer la toxicité cellulaire anticorps- dépendante (ADCC). Plus spécifiquement, l'invention concerne des méthodes d'utilisation d'antagonistes du récepteur d'hydrocarbure aryle (AHR) pour traiter le myélome multiple et améliorer l'ADCC. Un antagoniste CH233191 liposomal est en outre décrit.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)