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1. (WO2018085685) ANTIGENS FOR DETECTING TOXOPLASMA INFECTION BY MONITORING CELLULAR IMMUNITY

Pub. No.:    WO/2018/085685    International Application No.:    PCT/US2017/059978
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Sat Nov 04 00:59:59 CET 2017
IPC: A61K 39/02
A61K 39/00
Applicants: WASHINGTON UNIVERSITY
Inventors: SIBLEY, Laurence David
BROWN, Kevin M.
WANG, Qiuling
SARAAV, Iti
Title: ANTIGENS FOR DETECTING TOXOPLASMA INFECTION BY MONITORING CELLULAR IMMUNITY
Abstract:
Antigens of Toxoplasma gondii that provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-y secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-y secretion may be used.