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1. (WO2018085674) SMALL MOLECULE DUAL INHIBITORS OF EGFR/PI3K AND USES THEREOF

Pub. No.:    WO/2018/085674    International Application No.:    PCT/US2017/059958
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Sat Nov 04 00:59:59 CET 2017
IPC: A61K 31/517
C07D 239/94
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: WHITEHEAD, Christopher Emil
ZIEMKE, Elizabeth
SEBOLT-LEOPOLD, Judith
Title: SMALL MOLECULE DUAL INHIBITORS OF EGFR/PI3K AND USES THEREOF
Abstract:
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure which function as dual inhibitors EGFR and PI3K, and their use as therapeutics for the treatment of cancer (e.g., cancers associated with mutated KRAS and BRAF) (e.g., in combination with MAPK pathway inhibitors (e.g., BRAF inhibitors, MEK inhibitors, ERK inhibitors).