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1. (WO2018085622) LIVER ORGANOID DISEASE MODELS AND METHODS OF MAKING AND USING SAME
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Pub. No.: WO/2018/085622 International Application No.: PCT/US2017/059860
Publication Date: 11.05.2018 International Filing Date: 03.11.2017
IPC:
A61L 27/00 (2006.01) ,C12N 5/00 (2006.01) ,C12N 5/071 (2010.01)
[IPC code unknown for A61L 27][IPC code unknown for C12N 5][IPC code unknown for C12N 5/071]
Applicants:
CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnett Avenue Cincinnati, OH 45229, US
Inventors:
TAKEBE, Takanori; US
OUCHI, Rie; US
KIMURA, Masaki; US
Agent:
TEPE, Nicole, M.; US
SCHOEN, Ann, G.; US
GOLDSTEIN, Steven, J.; US
ACHESON, Edwin, R.; US
CONLEY, Scott, R.; US
Priority Data:
62/417,37104.11.2016US
62/517,41409.06.2017US
Title (EN) LIVER ORGANOID DISEASE MODELS AND METHODS OF MAKING AND USING SAME
(FR) MODÈLES PATHOLOGIQUES D'ORGANOÏDES HÉPATIQUES ET PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
Abstract:
(EN) Disclosed herein are methods of making and using lipotoxic organoid models. In certain aspects, the methods may comprise the steps of contacting a liver organoid with a free fatty acid (FFA) composition. In one aspect, the FFA composition may comprise oleic acid, linoleic acid, palmitic acid, or combinations thereof.
(FR) L'invention concerne des procédés de fabrication et d'utilisation de modèles d'organoïdes lipotoxiques. Dans certains aspects, les procédés selon l'invention peuvent comprendre les étapes consistant à mettre en contact un organoïde hépatique avec une composition d'acides gras libres (AGL). Dans un aspect, la composition d'AGL peut comprendre de l'acide oléique, de l'acide linoléique, de l'acide palmitique ou des combinaisons de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)