Search International and National Patent Collections

1. (WO2018085619) SUBSTITUTED PYRIDINONE-CONTAINING TRICYCLIC COMPOUNDS, AND METHODS USING SAME

Pub. No.:    WO/2018/085619    International Application No.:    PCT/US2017/059854
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Sat Nov 04 00:59:59 CET 2017
IPC: A61K 31/495
A61P 31/12
C07D 213/06
C07D 471/04
Applicants: ARBUTUS BIOPHARMA CORPORATION
Inventors: GOTCHEV, Dimitar, B.
DORSEY, Bruce, D.
KAKARLA, Ramesh
BI, Yingzhi
NGUYEN, Duyan
CHEN, Shuai
WOOD, Mark, Christopher
HOLLAND, Richard, James
BAILEY, Laurèn, Danielle
Title: SUBSTITUTED PYRIDINONE-CONTAINING TRICYCLIC COMPOUNDS, AND METHODS USING SAME
Abstract:
The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.