Search International and National Patent Collections

1. (WO2018085555) ACTIVATABLE ANTI-CTLA-4 ANTIBODIES AND USES THEREOF

Pub. No.:    WO/2018/085555    International Application No.:    PCT/US2017/059740
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Fri Nov 03 00:59:59 CET 2017
IPC: C07K 16/28
C07K 19/00
A61K 39/395
A61P 35/00
Applicants: BRISTOL-MYERS SQUIBB COMPANY
CYTOMX THERAPEUTICS, INC.
Inventors: TIPTON, Kimberly Ann
WEST, James William
DESHPANDE, Shrikant
ENGELHARDT, John J.
Title: ACTIVATABLE ANTI-CTLA-4 ANTIBODIES AND USES THEREOF
Abstract:
Provided herein are activatable anti-human CTLA-4 antibodies comprising a heavy chain comprising a VH domain and a light chain comprising a masking moiety (MM), a cleavable moiety (CM), and a VL domain. Such activatable anti-human CTLA-4 antibodies have CTLA-4 binding activity in the tumor microenvironment, where the masking moiety is removed by proteolytic cleavage of the cleavable moiety by tumor-specific proteases, but exhibit greatly reduced binding to CTLA-4 outside the tumor. In this way, the activatable anti-human CTLA-4 antibodies of the present invention retain anti-tumor activity while reducing the side effects associated with anti-CTLA-4 activity outside the tumor.