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|1. (WO2018085493) ENDOTOXIN FREE ASPARAGINASE|
|Applicants:||GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
|Inventors:||PIERCE, George, E.
CROW, Sidney, A.
|Title:||ENDOTOXIN FREE ASPARAGINASE|
Disclosed herein is an endotoxin-free asparaginase enzyme. Also disclosed are methods of using the disclosed enzyme to treat subjects with a disease treatable by depletion of asparagine. For example, the disclosed endotoxin-free asparaginase enzyme is useful in the treatment or the manufacture of a medicament for use in the treatment of acute lymphoblastic leukemia (ALL) in both adults and children, as well as other conditions where asparagine depletion is expected to have a useful effect.