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1. (WO2018085493) ENDOTOXIN FREE ASPARAGINASE

Pub. No.:    WO/2018/085493    International Application No.:    PCT/US2017/059655
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Fri Nov 03 00:59:59 CET 2017
IPC: C12N 1/22
C12N 1/20
C12N 9/06
C12N 9/78
C12N 9/82
C12N 9/88
C12N 15/09
C07H 21/04
A61K 38/46
A61K 38/43
A61K 38/54
Applicants: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors: PIERCE, George, E.
CROW, Sidney, A.
Title: ENDOTOXIN FREE ASPARAGINASE
Abstract:
Disclosed herein is an endotoxin-free asparaginase enzyme. Also disclosed are methods of using the disclosed enzyme to treat subjects with a disease treatable by depletion of asparagine. For example, the disclosed endotoxin-free asparaginase enzyme is useful in the treatment or the manufacture of a medicament for use in the treatment of acute lymphoblastic leukemia (ALL) in both adults and children, as well as other conditions where asparagine depletion is expected to have a useful effect.