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1. (WO2018085491) 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS

Pub. No.:    WO/2018/085491    International Application No.:    PCT/US2017/059651
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Fri Nov 03 00:59:59 CET 2017
IPC: A61K 31/395
A61K 31/404
A61K 31/519
A61K 31/165
Applicants: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
U.S. DEPARTMENT OF VETERANS AFFAIRS
Inventors: LINDSEY, Christopher, C.
BEESON, Craig, C.
SCHNELLMANN, Rick, G.
Title: 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS
Abstract:
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.