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1. (WO2018085468) ANTIBODIES DIRECTED AGAINST PROGRAMMED DEATH- 1 (PD-1)

Pub. No.:    WO/2018/085468    International Application No.:    PCT/US2017/059618
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Thu Nov 02 00:59:59 CET 2017
IPC: A61K 39/395
C07K 16/28
C12N 15/13
Applicants: ANAPTYSBIO, INC.
TESARO, INC.
Inventors: KING, David J.
KEHRY, Marilyn
HUANG, Baochuan
Title: ANTIBODIES DIRECTED AGAINST PROGRAMMED DEATH- 1 (PD-1)
Abstract:
The disclosure provides antibody agents that bind to a programmed death-1 (PD-1) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using the anti-PD-1 antibody agent to treat a disorder or disease that is responsive to PD-1 inhibition, such as cancer or an infectious disease.