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1. (WO2018085453) MICROFLUIDIC DEVICES AND METHODS FOR PURIFYING RARE ANTIGEN-SPECIFIC T CELL POPULATIONS

Pub. No.:    WO/2018/085453    International Application No.:    PCT/US2017/059598
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Thu Nov 02 00:59:59 CET 2017
IPC: B01L 3/00
B01F 15/00
G01N 27/417
G01N 33/48
G02B 21/32
C12M 1/34
Applicants: CALIFORNIA INSTITUTE OF TECHNOLOGY
GWANG INSTITUTE OF SCIENCE AND TECHNOLOGY (GIST)
Inventors: PENG, Songming
HEATH, James, R.
CHOUR, William
NG, Alphonsus, H.C.
YANG, Sung
CHOI, Jongchan
HYUN, Ji-chul
Title: MICROFLUIDIC DEVICES AND METHODS FOR PURIFYING RARE ANTIGEN-SPECIFIC T CELL POPULATIONS
Abstract:
Disclosed herein are methods and devices for antigen-specific T cell identification or neoantigen identification. Also disclosed herein are devices for separating and isolating antigen- specific T cells or other particles of a certain size from a population of particles of different sizes. Also describe herein are methods and devices for the separation and isolation of barcoded T cells from other nanoparticles containing barcodes for subsequent analysis and further processing of a viable T cell.