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1. WO2018085436 - AGENTS AND METHODS FOR TREATING CREB BINDING PROTEIN-DEPENDENT CANCERS

Publication Number WO/2018/085436
Publication Date 11.05.2018
International Application No. PCT/US2017/059579
International Filing Date 01.11.2017
IPC
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
C07K 14/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16HIV-1
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07K 14/4705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
4705stimulating, promoting or activating activity
C07K 2319/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
01containing a localisation/targetting motif
10containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Applicants
  • MEMORIAL SLOAN KETTERING CANCER CENTER [US]/[US]
Inventors
  • KENTSIS, Alex
  • RAMASWAMY, Kavitha
  • FORBES, Lauren
Agents
  • COHEN, Mark, S.
  • COHEN, Mark S.
Priority Data
62/415,80001.11.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AGENTS AND METHODS FOR TREATING CREB BINDING PROTEIN-DEPENDENT CANCERS
(FR) AGENTS ET MÉTHODES SERVANT AU TRAITEMENT DE CANCERS DÉPENDANT DE LA PROTÉINE DE LIAISON À LA CREB
Abstract
(EN)
Single chain peptides comprising either a cell penetrating HIV-TAT peptide sequence and a MYB:CBP complex interfering peptide sequence from MYB, or compsiring a cell penetrating HIV-TAT peptide sequence, a CBP binding peptide sequence from CREB and a MYB:CBP complex interfering peptide sequence from MYB, are provided for use in preventing MYB:CBP complex formation and downstream events leading to cancer, in particular a leukemia. Both L-amino acid single chain peptides and retro-inverso single chain peptides are provided.
(FR)
L'invention concerne des peptides à chaîne unique comprenant soit une séquence de peptide de pénétration cellulaire TAT du VIH et une séquence de peptide interférant du complexe MYB:CBP provenant de MYB, soit une séquence de peptide de pénétration cellulaire TAT du VIH, une séquence de peptide de liaison à la CBP provenant de la CREB et une séquence de peptide interférant du complexe MYB:CBP provenant de MYB, visant à empêcher la formation du complexe MYB:CBP et les événements en aval conduisant au cancer, en particulier une leucémie. L'invention concerne aussi bien des peptides à chaîne unique de type acide aminé lévogyre que des peptides à chaîne unique de type rétro-inverso.
Also published as
Latest bibliographic data on file with the International Bureau