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1. (WO2018085263) COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/085263    International Application No.:    PCT/US2017/059270
Publication Date: 11.05.2018 International Filing Date: 31.10.2017
IPC:
A61K 45/00 (2006.01), C12Q 1/02 (2006.01), G01N 33/569 (2006.01), A61P 25/00 (2006.01)
Applicants: RESILIO THERAPEUTICS, LLC [US/US]; 923 Bluestone Rd Durham, North Carolina 27713 (US)
Inventors: TAVARES, Francis Xavier; (US).
VITEK, Michael Peter; (US)
Agent: WOO, Justin N.; (US).
ARORA, Suneel, Reg. No. 42,267; (US).
BEEKMAN, Marvin L., Reg. No. 38,377; (US).
BIANCHI, Timothy E., Reg. No. 39,610; (US).
BLACK, David W., Reg. No. 42,331; (US).
MCCRACKIN, Ann M., Reg. No. 42,858; (US).
PERDOK, Monique M., Reg. No. 42,989; (US).
SCHEER, Bradley W., Reg. No. 47,059; (US)
Priority Data:
62/415,590 01.11.2016 US
Title (EN) COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
(FR) COMPOSÉS POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
Abstract: front page image
(EN)Novel compounds of formula (II) are disclosed. Compounds of formula (II) comprise ornithine derivatives or compounds that can metabolize under physiological conditions to ornithine. The pH and plasma stability of compounds of formula (II) is also described. Also disclosed are methods for the treatment of neurodegenerative diseases such as Alzheimer's Disease using compounds of formula (II).
(FR)L'invention concerne de nouveaux composés de formule (II). Ces composés de formule (II) comprennent des dérivés d'ornithine ou des composés qui peuvent se métaboliser dans des conditions physiologiques en ornithine. L'invention concerne également le pH et la stabilité au plasma des composés de formule (II). L'invention concerne également des procédés pour traiter des maladies neurodégénératives, telles que la maladie d'Alzheimer, à l'aide de composés de formule (II).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)