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1. (WO2018085229) RESISTANT CELL LINES AND METHODS OF TREATING CANCER USING COMBINATION OF HDAC6 INHIBITOR AND BTK PATHWAY INHIBITOR

Pub. No.:    WO/2018/085229    International Application No.:    PCT/US2017/059203
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Wed Nov 01 00:59:59 CET 2017
IPC: C12N 5/09
C12N 5/0781
A61P 35/00
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Inventors: AMENGUAL, Jennifer, E.
O'CONNOR, Owen, A.
Title: RESISTANT CELL LINES AND METHODS OF TREATING CANCER USING COMBINATION OF HDAC6 INHIBITOR AND BTK PATHWAY INHIBITOR
Abstract:
Provided herein is a new therapeutic regimen comprising an HDAC6 inhibitor and a BKT inhibitor for the treatment of lymphoma. More specifically, the regimen comprises treatment with ACY-1215 and ibrutinib. Furthermore, the invention provides a lymphoma cell line resistant to the HDAC6 selective inhibition.