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1. (WO2018085148) NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AS FXR MODULATORS

Pub. No.:    WO/2018/085148    International Application No.:    PCT/US2017/058802
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Sat Oct 28 01:59:59 CEST 2017
IPC: C07D 413/14
C07D 417/14
C07D 487/04
A61K 31/4427
A61K 31/496
Applicants: HEPAGENE THERAPEUTICS, INC.
XU, Xiaodong
Inventors: XU, Xiaodong
Title: NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AS FXR MODULATORS
Abstract:
The present technology is directed to compounds, compositions, and methods related to modulation of FXR. In particular, the present compounds and compositions may be used to treat FXR-mediated disorders and conditions, including, e.g., liver disease, hyperlipidemia, hypercholesteremia, obesity, metabolic syndrome, cardiovascular disease, gastrointestinal disease, and atherosclerosis, and renal disease.