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1. (WO2018084806) ZINC-γ-PGA COMPOSITIONS AND METHODS FOR TREATING CANCER

Pub. No.:    WO/2018/084806    International Application No.:    PCT/SG2017/050545
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Wed Nov 01 00:59:59 CET 2017
IPC: A61K 33/30
A61K 47/64
A61P 35/00
Applicants: XYLONIX IP HOLDINGS PTE. LTD.
Inventors: CHUNG, Jinhyuk Fred
Title: ZINC-γ-PGA COMPOSITIONS AND METHODS FOR TREATING CANCER
Abstract:
The invention relates to pharmaceutical compositions comprising a zinc2+ salt and a γ-polyglutamic acid carrier, and, optionally, an NF-kB inhibitor as a tumor-sensitizing agent, and methods for using such compositions to treat tumors in patients. Methods include administering a liquid dosage form or a solid dosage form of a therapeutically effective amount of a Zn(ll) salt and a γ-polyglutamic acid carrier to a patient in need thereof. Methods of treating a broad spectrum of human tumors, including tumors with a drug-resistant phenotype, using the disclosed compositions are provided. Tumors that respond to the pharmaceutical compositions disclosed herein include neuroendocrine (neuroblastoma), gastric, uterine, and lung tumors.