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1. (WO2018084806) ZINC-γ-PGA COMPOSITIONS AND METHODS FOR TREATING CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/084806 International Application No.: PCT/SG2017/050545
Publication Date: 11.05.2018 International Filing Date: 31.10.2017
IPC:
A61K 33/30 (2006.01) ,A61K 47/64 (2017.01) ,A61P 35/00 (2006.01)
Applicants: XYLONIX IP HOLDINGS PTE. LTD.[SG/SG]; 10 Anson Road, #28-05A, International Plaza Singapore 079903, SG
Inventors: CHUNG, Jinhyuk Fred; SG
Agent: PIZZEYS PTE LTD; 152 Beach Road, #04-08 Gateway East Singapore 189721, SG
Priority Data:
10201609131Y01.11.2016SG
Title (EN) ZINC-γ-PGA COMPOSITIONS AND METHODS FOR TREATING CANCER
(FR) COMPOSITIONS DE ZINC-γ-PGA ET PROCÉDÉS DE TRAITEMENT DU CANCER
Abstract: front page image
(EN) The invention relates to pharmaceutical compositions comprising a zinc2+ salt and a γ-polyglutamic acid carrier, and, optionally, an NF-kB inhibitor as a tumor-sensitizing agent, and methods for using such compositions to treat tumors in patients. Methods include administering a liquid dosage form or a solid dosage form of a therapeutically effective amount of a Zn(ll) salt and a γ-polyglutamic acid carrier to a patient in need thereof. Methods of treating a broad spectrum of human tumors, including tumors with a drug-resistant phenotype, using the disclosed compositions are provided. Tumors that respond to the pharmaceutical compositions disclosed herein include neuroendocrine (neuroblastoma), gastric, uterine, and lung tumors.
(FR) La présente invention concerne des compositions pharmaceutiques comprenant un sel de zinc2+ et un support d’acide γ-polyglutamique, et, facultativement, un inhibiteur de NF-kB en tant qu’agent de sensibilisation de tumeur, et des procédés d’utilisation de telles compositions pour traiter des tumeurs chez des patients. Les procédés comprennent l’administration d’une forme posologique liquide ou d’une forme pharmaceutique solide d’une quantité thérapeutiquement efficace d’un sel de Zn(ll) et d’un support d’acide γ-polyglutamique à un patient en ayant besoin. L’invention concerne en outre des procédés de traitement d’un large spectre de tumeurs humaines, comprenant des tumeurs présentant un phénotype pharmacorésistant, au moyen des compositions de l’invention. Les tumeurs qui répondent aux compositions pharmaceutiques de l’invention comprennent des tumeurs neuroendocrines (neuroblastome), gastriques, utérines et pulmonaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)