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1. (WO2018084650) VECTOR FOR EXPRESSING HUMAN EPIDERMAL GROWTH FACTOR OR SKIN-PERMEABLE HUMAN EPIDERMAL GROWTH FACTOR, AND MICROALGAE TRANSFORMED WITH VECTOR
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Pub. No.:    WO/2018/084650    International Application No.:    PCT/KR2017/012437
Publication Date: 11.05.2018 International Filing Date: 03.11.2017
IPC:
C12N 15/79 (2006.01), C12P 21/00 (2006.01), C07K 14/485 (2006.01), A61K 8/64 (2006.01), A61Q 19/00 (2006.01), A61Q 19/08 (2006.01)
Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY [KR/KR]; 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792 (KR)
Inventors: PAN, Cheol-Ho; (KR).
SHIN, Bok-Kyu; (KR).
ERDENE-OCHIR, Erdenedolgor; (KR).
KIM, Sang Min; (KR)
Agent: KIM, Sun-young; (KR)
Priority Data:
10-2016-0146839 04.11.2016 KR
10-2017-0145448 02.11.2017 KR
Title (EN) VECTOR FOR EXPRESSING HUMAN EPIDERMAL GROWTH FACTOR OR SKIN-PERMEABLE HUMAN EPIDERMAL GROWTH FACTOR, AND MICROALGAE TRANSFORMED WITH VECTOR
(FR) VECTEUR D’EXPRESSION DU FACTEUR DE CROISSANCE ÉPIDERMIQUE HUMAIN OU DU FACTEUR DE CROISSANCE ÉPIDERMIQUE HUMAIN PERMÉABLE AU NIVEAU DE LA PEAU, ET MICROALGUE TRANSFORMÉE AVEC LE VECTEUR
(KO) 인간상피세포 성장인자 또는 피부침투성 인간상피세포 성장인자 발현용 벡터 및 상기 벡터로 형질전환된 미세조류
Abstract: front page image
(EN)The present specification relates to: a vector comprising a promoter of SEQ ID NO: 1 and a human epidermal growth factor (hEGF) exon, which includes a gene coding for hEGF; microalgae transformed with the vector; a method for producing a hEGF protein and/or a PTD-hEGF protein by using the transformed microalgae; and a cosmetic composition containing the hEGF and/or PTD-hEGF protein(s) produced according to the production method. The hEGF and PTD-hEGF proteins, produced according to an aspect of the present invention, can fundamentally block the risk of endotoxicity, unlike a hEGF protein produced from conventional E. coli, thereby being usable as a raw material for eco-friendly cosmetic products.
(FR)La présente invention concerne : un vecteur comprenant un promoteur de SEQ ID no : 1 et un exon de facteur de croissance épidermique humain (hEGF), qui comprend un gène codant pour le hEGF ; la microalgue transformée avec le vecteur ; un procédé de production d’une protéine hEGF et/ou d’une protéine PTD-hEGF en utilisant la microalgue transformée ; et une composition cosmétique contenant la(les) protéine(s) hEGF et/ou PTD-hEGF produites selon le procédé de production. Les protéines hEGF et PTD-hEGF, produites selon un aspect de la présente invention, peuvent bloquer fondamentalement le risque d’endotoxicité, contrairement à une protéine hEGF produite à partir d’E. coli classique, étant ainsi utilisable comme matière première pour les produits cosmétiques respectueux de l’environnement.
(KO)본 명세서는 서열번호 1의 프로모터; 및 인간 상피세포 성장인자(hEGF)를 코딩하는 유전자를 포함하는 hEGF 발현구역;을 포함하는 벡터, 상기 벡터로 형질전환된 미세조류, 상기 형질전환된 미세조류를 이용하여 hEGF 단백질 및 PTD-hEGF 단백질 중 어느 하나 이상을 생산하는 방법 및 상기 생산방법에 따라 제조된 hEGF 단백질 및 PTD-hEGF 단백질 중 어느 하나 이상을 포함하는 화장료 조성물에 관한 것으로, 본 발명의 일측면에 따라 생산된 hEGF 단백질 및 PTD-hEGF 단백질은 기존 대장균에서 생산되는 hEGF 단백질과 달리 내성독성의 위험을 원천 봉쇄할 수 있어, 친환경 화장품의 원료로 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)