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1. (WO2018084236) ANTIBODY AGAINST PRORENIN RECEPTOR OR ANTIGEN-BINDING FRAGMENT OF SAID ANTIBODY, AND USE OF SAME

Pub. No.:    WO/2018/084236    International Application No.:    PCT/JP2017/039702
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Fri Nov 03 00:59:59 CET 2017
IPC: C07K 16/28
A61K 39/395
A61P 35/00
C07K 16/46
G01N 33/574
C12N 15/09
C12P 21/08
Applicants: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
国立大学法人香川大学
GIFU UNIVERSITY
国立大学法人岐阜大学
SOWAKAI MEDICAL FOUNDATION
医療法人創和会
Inventors: NISHIYAMA Akira
西山 成
MATSUYAMA Makoto
松山 誠
EBIHARA Akio
海老原 章郎
Title: ANTIBODY AGAINST PRORENIN RECEPTOR OR ANTIGEN-BINDING FRAGMENT OF SAID ANTIBODY, AND USE OF SAME
Abstract:
Provided is a novel antibody against a prorenin receptor or an antigen-binding fragment of the antibody, which can detect a prorenin receptor. The antibody against a prorenin receptor or an antigen-binding fragment of the antibody according to the present invention is characterized by being capable of binding to a prorenin receptor, and is also characterized by comprising a heavy-chain variable region and a light-chain variable region, wherein the combination of the heavy-chain variable region and the light-chain variable region is as follows: the heavy-chain variable region contains the amino acid sequences (H1-a1), (H2-a1) and (H3-a1) and the light-chain variable region contains the amino acid sequences (L1-a1), (L2-a1) and (L3-a1).