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1. (WO2018083704) USE OF HEXOKINASE 2/MITOCHONDRIA-DETACHING COMPOUNDS FOR ACTIVATING IMMUNE RESPONSES

Pub. No.:    WO/2018/083704    International Application No.:    PCT/IL2017/051213
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Wed Nov 08 00:59:59 CET 2017
IPC: A61K 31/47
A61K 31/496
A61P 37/04
A61P 35/00
C07D 215/48
C07D 403/06
Applicants: VIDAC PHARMA LTD.
Inventors: BEHAR, Vered
BECKER, Oren Menahem
YOSEF HAMO, Reut
DOR-ON, Eyal
Title: USE OF HEXOKINASE 2/MITOCHONDRIA-DETACHING COMPOUNDS FOR ACTIVATING IMMUNE RESPONSES
Abstract:
The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for inducing immune responses in a subject, including potentiating the immune response to hyperproliferative disorders such as cancer and potentiating the immune response to infectious diseases.