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1. (WO2018083693) METHODS AND KITS FOR DIAGNOSING AND MONITORING TREATMENT OF BLOOD-BORNE PARASITES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/083693    International Application No.:    PCT/IL2017/051193
Publication Date: 11.05.2018 International Filing Date: 01.11.2017
IPC:
C12Q 1/68 (2006.01), C12N 15/113 (2010.01)
Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. [IL/IL]; The Chaim Sheba Medical Center Tel HaShomer 5262000 Ramat-Gan (IL)
Inventors: AVNI, Dror; (IL).
SCHWARTZ, Eli; (IL).
SIDI, Yechezkel; (IL)
Agent: G. E. EHRLICH (1995) LTD.; 11 Menachem Begin Road 5268104 Ramat Gan (IL).
EHRLICH, Gal; (IL).
WATERMAN, Hadassa; (IL).
MELNICK, Geoffrey, L.; (IL)
Priority Data:
62/415,729 01.11.2016 US
Title (EN) METHODS AND KITS FOR DIAGNOSING AND MONITORING TREATMENT OF BLOOD-BORNE PARASITES
(FR) MÉTHODES ET KITS POUR DIAGNOSTIQUER ET SURVEILLER LE TRAITEMENT DE PARASITES HÉMATOGÈNE
Abstract: front page image
(EN)A method of diagnosing an infection by a blood-borne parasite in a subject in need thereof is provided. The method comprising: (a) isolating an exosomal fraction from a blood sample of the subject; (b) determining a presence or level of an RNA molecule of said parasite in said exosomal fraction, wherein said presence or level of said RNA molecule in said exosomal fraction is indicative of the infection, thereby diagnosing the infection by the blood-borne parasite. Also provided are methods of monitoring disease progression and treatment efficacy.
(FR)L'invention concerne une méthode de diagnostic d'une infection par un parasite hématogène chez un sujet en ayant besoin. La méthode consiste à : (a) isoler une fraction exosomale d'un échantillon de sang du sujet; (b) déterminer une présence ou un niveau d'une molécule d'ARN dudit parasite dans ladite fraction exosomale, ladite présence ou ledit niveau de ladite molécule d'ARN dans ladite fraction exosomale étant indicatif de l'infection, ce qui permet de diagnostiquer l'infection par le parasite hématogène. L'invention concerne également des méthodes de surveillance de la progression de la maladie et de l'efficacité du traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)