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1. WO2018083635 - TRICYCLIC HETEROCYCLIC DERIVATIVES AND USES THEREOF

Publication Number WO/2018/083635
Publication Date 11.05.2018
International Application No. PCT/IB2017/056848
International Filing Date 03.11.2017
IPC
C07D 219/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
219Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
06Oxygen atoms
C07D 311/86 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
84with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
86Oxygen atoms, e.g. xanthones
C07D 219/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
219Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
14with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
C07D 335/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
335Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
04condensed with carbocyclic rings or ring systems
10Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
12Thioxanthenes
A61K 31/435 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
A61K 31/35 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Applicants
  • AUCKLAND UNISERVICES LIMITED [NZ]/[NZ]
Inventors
  • GAMAGE, Swarnalatha Akuratiya
  • SHEPHERD, Peter Robin
  • FLANAGAN, Jack Urquhart
  • REWCASTLE, Gordon William
  • MARSHALL, Andrew James
  • BUCHANAN, Christina Maree
  • LU, Guo-Liang
  • BONNET, Muriel
  • JAMIESON, Stephen Michael Frazer
  • DENNY, William Alexander
Agents
  • AJ PARK
Priority Data
72576704.11.2016NZ
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC HETEROCYCLIC DERIVATIVES AND USES THEREOF
(FR) DÉRIVÉS HÉTÉROCYCLIQUES TRICYCLIQUES ET LEURS UTILISATIONS
Abstract
(EN)
Disclosed are tricyclic heterocyclic compounds having kinase inhibitory activity, pharmaceutical compositions and kits comprising the compounds, and use of the compounds in the treatment of or in medicaments for the treatment of various diseases and conditions. In particular, disclosed are tricyclic heterocyclic compounds of the formula (I) having CSF-1R (c-FMS kinase) inhibitory activity and their use in the treatment of various diseases and conditions, such as those mediated by CSF-1R, including proliferative or neoplastic diseases and conditions, including cancers, and bone, inflammatory, and autoimmune diseases and conditions.
(FR)
L'invention concerne des composés hétérocycliques tricycliques ayant une activité inhibitrice de kinase, des compositions pharmaceutiques et des kits comprenant les composés, et l'utilisation des composés dans le traitement ou dans des médicaments pour le traitement de diverses maladies et affections. En particulier, l'invention concerne des composés hétérocycliques tricycliques de formule (I) ayant une activité inhibitrice de CSF-1R (c-FMS kinase) et leur utilisation dans le traitement de diverses maladies et affections, telles que celles médiées par le CSF-1R, y compris des maladies et affections prolifératives ou néoplasiques, y compris des cancers, et des maladies et affections osseuses, inflammatoires et auto-immunes.
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