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1. (WO2018083635) TRICYCLIC HETEROCYCLIC DERIVATIVES AND USES THEREOF

Pub. No.:    WO/2018/083635    International Application No.:    PCT/IB2017/056848
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Sat Nov 04 00:59:59 CET 2017
IPC: C07D 219/06
C07D 311/86
C07D 219/14
C07D 335/12
A61K 31/435
A61K 31/35
A61P 35/00
A61P 19/02
Applicants: AUCKLAND UNISERVICES LIMITED
Inventors: GAMAGE, Swarnalatha Akuratiya
SHEPHERD, Peter Robin
FLANAGAN, Jack Urquhart
REWCASTLE, Gordon William
MARSHALL, Andrew James
BUCHANAN, Christina Maree
LU, Guo-Liang
BONNET, Muriel
JAMIESON, Stephen Michael Frazer
DENNY, William Alexander
Title: TRICYCLIC HETEROCYCLIC DERIVATIVES AND USES THEREOF
Abstract:
Disclosed are tricyclic heterocyclic compounds having kinase inhibitory activity, pharmaceutical compositions and kits comprising the compounds, and use of the compounds in the treatment of or in medicaments for the treatment of various diseases and conditions. In particular, disclosed are tricyclic heterocyclic compounds of the formula (I) having CSF-1R (c-FMS kinase) inhibitory activity and their use in the treatment of various diseases and conditions, such as those mediated by CSF-1R, including proliferative or neoplastic diseases and conditions, including cancers, and bone, inflammatory, and autoimmune diseases and conditions.