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1. (WO2018083607) SYNP198, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN DIRECTION SELECTIVE RETINAL GANGLION CELLS

Pub. No.:    WO/2018/083607    International Application No.:    PCT/IB2017/056792
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Thu Nov 02 00:59:59 CET 2017
IPC: A61K 48/00
C12N 15/85
Applicants: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
Inventors: HARTL, Dominik
JUETTNER, Josephine
KREBS, Arnaud
ROSKA, Botond
SCHUEBELER, Dirk
Title: SYNP198, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN DIRECTION SELECTIVE RETINAL GANGLION CELLS
Abstract:
The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in direction selective retinal ganglion cells of a gene when operatively linked to a nucleic acid sequence coding for said gene.